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Development of microangiopathy and markers of macrovascular complications precedes these events. In this thesis we first Study I aimed to investigate early signs of atherosclerosis, measured as carotid intima-media thickness cIMT , and its relation to insulin sensitivity in young type 1 diabetes individuals. Then we compared Study II skin microvascular function in the foot and the time to first of hospitalization for ischemic foot ulcer in between the two groups in the SDIS cohort. Finally, we investigated Study IV long-term survival in individuals with type 1 diabetes, type 2 diabetes and without diabetes following coronary artery bypass grafting CABG. The outcome measures were all-cause mortality, mortality in CVD death and any major adverse coronary event, i.